DESIGN, SYNTHESIS, AND INVESTIGATION OF NOVEL NITRIC OXIDE (NO)-RELEASING AROMATIC ALDEHYDES AS DRUG CANDIDATES FOR THE TREATMENT OF SICKLE CELL DISEASE

Sickle cell disease (SCD) is caused by a single-point mutation, and the ensuing deoxygenation-induced polymerization of sickle hemoglobin (HbS), and reduction in bioavailability of vascular nitric oxide (NO), contribute to the pathogenesis of the disease.In a proof-of-concept study, we successfully incorporated nitrate ester groups onto two previou

John Amos Comenius was a revolutionary leader in both the church and the academy in 17th century Europe.Born and raised in Moravia and firmly grounded in the doctrine of the United Church of the Brethren, Comenius rose from obscurity in what is now the Czech Republic to become recognized around Europe and beyond as an innovative Sectional and trans

Consumers are increasingly practicing an alternative model of Dog Jacket politics when they make food choices influenced by civic concerns.The new markets that emerge in this context carry specific modes of qualification that makes food products valuable not only for their intrinsic properties, but also for features associated with their production

The article presents the analysis of application of hybrid propulsion systems combining conventional diesel with electric drive for units used in inland transport.The answer is given to the question: to what extent will the use of different configurations of hybrid Loungewear systems, affect the reduction of fuel consumption and reduce poisonous ga

This paper presents the state of the art in Structural Reliability Analysis (SRA) methods with a view of identifying key applications of each method and its proposed variations, qualifying characteristics, advantages, and limitations.Due to the increasing complexity and scale of modern offshore jacket structures, it becomes increasingly necessary t